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SUPPORT US IN OUR MISSION TO SAVE LIVES OF CHILDREN WITH MISDIAGNOSED HEART DISEASE

LATEST RESEARCH

We are committed to supporting parents who want to learn more about Kawasaki Disease and provide them with the most recent resources.

 

Adult life after KD

KD usually presents in children under five years old. Children with KD may require life-long treatment, however, since the acute phase of KD is self-limited, KD diagnosis is often missed. Consequently, individuals reach adulthood unaware of their KD history and face multiple cardiac complications. In the US and Japan alone, more than 14,000 new cases of KD are detected each year, yet no official guidelines exist to assist cardiologists in treating patients with a KD history.

Once an individual’s normal arterial wall architecture has been damaged during the acute, inflammatory phase of KD, the affected segment will always have abnormal characteristics. Characteristics resulting from KD earlier in life can contribute to pathological cardiovascular conditions known as cardiovascular sequelae in adulthood. Growing numbers of young adults are presenting to cardiologists cardiovascular sequelae resulting from KD, including…

  • Cardiomyopathy (a disease of the heart muscle making it harder for the heart to pump blood around the body).

  • Myocardial ischemia (insufficient blood supply to the heart tissue).

  • Myocardial infarction (heart attack).

  • Proliferation of myofibroblasts.

  • Inability of the CA to dilate in times where myocardial oxygen demand is greater due to the arterial wall’s abnormal composition and calcification.

  • Propensity to develop aneurisms in systemic arteries (arteries carrying blood from the heart to the body), and patients may present with symptoms of ischemia including weakness in a limb or extremity. These aneurisms have a high propensity to clot, sometimes completely, though many patients do well and can manage this symptom with low-dose aspirin and statins, avoiding bypass surgery.

The management of cardiovascular sequelae conditions is different from atherosclerotic heart disease but there is little awareness in the adult cardiology community regarding the special challenges posed by cardiovascular sequelae of KD. For example, coronary artery aneurisms which can cause insufficient BP and myocardial ischemia in patients with KD history are associated with high risk of thrombosis (clotting) and stenosis (blocking or narrowing) at aneurism. These aneurisms are often highly calcified. In healthy individuals, narrowing of blood vessels can be treated with acetylcholine which induces vasodilation, however, in patients with cardiovascular sequelae from KD, the endothelium of the coronary artery demonstrates paradoxical vasoconstriction in response to this treatment, and thus treatment with acetylcholine is ineffective.

It is therefore crucial for cardiologists to be able to make retrospective KD diagnosis with their adult patients. Cardiologists should, therefore, be familiar with KD signs and symptoms. It is also advised that doctors question the patient's parents about KD-compatible illness. Imaging studies such as magnetic resonance can also be useful. The detection of calcification of the arterial wall at places of former aneurysms is a sign of KD antecedent. However, since the KD etiology remains unknown, no specific test can be conducted for a retrospective KD diagnosis.


KD disease remains enigmatic. To improve the care of patients with antecedent KD, more systematic studies are necessary to collect data about patient histories and outcomes. This will allow the formulation of a hypothesis about the appropriate care and their test under clinical studies.

Research by Dr. J. Burns, UC San Diego School of Medicine 

Pregnancy after KD

Due to the relatively recent discovery of KD and lack of awareness of the disease, research into the effects of the disease during and following pregnancy is scarce and sample sizes in studies are generally small. All cardiovascular sequelae of KD pose risks to the mother during pregnancy, labour and delivery, and medications used to manage these conditions may pose risks to the foetus.

 

In the most recent study of 10 women with a history of KD, only one experienced an obstetrical complication of post-partum haemorrhage, which was possibly related to premature re-institution of heparin therapy after delivery (1). This highlights the need for more studies into the management of KD and associated cardiovascular sequelae in order to develop evidence-based guidelines for obstetricians to support the mothers and babies affected by KD.

Two women in this study delivered infants that developed KD at two and five months. Both mothers were unaware of the genetic component to susceptibility to KD and were unfamiliar with the characteristic clinical signs of KD because they had no personal memory of their illness in childhood. This underscores the need to improve knowledge of the disease’s genetic risk in people with history of the disease.

The study also reviewed reports of the management, delivery method and outcomes in 52 Japanese women with a history of KD. Obstetrical complications were reported in 9.7% of the deliveries including premature rupture of membranes, preterm labor, and post-partum hemorrhage. Cardiovascular complications were also reported in 9.6% of the women. Of the 72 infants, 63 were delivered at term and were healthy; two infants were delivered prematurely at 33 weeks by caesarean section due to maternal distress; five additional infants were born prematurely; two additional infants had congenital abnormalities consisting of ventricular septal defect (hole in the heart) and agenesis of the corpus callosum.

1. Gordon CT, Jimenez-Fernandez S, Daniels LB, et al. Pregnancy in women with a history of Kawasaki disease: management and outcomes. BJOG. 2014;121(11):1431–1438. doi:10.1111/1471-0528.12685

 

Latest Research

Watch this space for key updates and publications.

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For more information visit the website for the Kawasaki Disease Foundation, a national parent organization committed to increasing awareness and education about Kawasaki Disease: http://www.pediatrics.ucsd.edu/kawasaki http://www.kdfoundation.org